Taub Institute: Genomics Core
AN NIA-FUNDED ALZHEIMER'S DISEASE RESEARCH CENTER
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Research

Genetics


Overview
The Laboratory for Genetic Epidemiology at Columbia University has been studying Alzheimer's disease (AD) across different ethnic populations for nearly 20 years. Led by Richard Mayeux, the lab continues to play a leadership role in the National Institute on Aging (NIA) Genetics Initiative. The NIA Family Study of Alzheimer'’s Disease, which includes approximately 1,500 families multiply affected by late-onset Alzheimer's disease (LOAD), is one of the most sought after cohorts for genetic studies in the world. In addition, Mayeux and his team direct the scientific community’s largest family study of Caribbean Hispanics, which includes over 700 multiplex families affected by AD. They are also actively engaged in a multi-national effort, which previously identified genetic variants in the SORL1 as a putative genetic risk factor for Alzheimer's disease. In addition, as a senior investigator in the Alzheimer's Disease Genetics Consortium project, Dr. Mayeux and team continue to use genome-wide association (GWA) methods to identify AD genes and have begun whole exome sequencing and targeted sequencing studies. Presently, the lab is focused on investigations of the both risk and protective variants for early-onset and late-onset AD. In addition, they conduct studies of environmental and medical risk factors, the genotypic variability of apolipoprotein-E risk among different ethnic groups, and the relationship between alterations in lipid metabolism and risk of dementia.

Also see: http://www.cumc.columbia.edu/dept/sergievsky/is.html

Grants Current Projects Contact
Alzheimer's Disease Genetics Consortium (ADGC) ADGC Projects Richard Mayeux
Genetic Epidemiology of Alzheimer's Disease In Hispanics (EFIGA)
Targeted Sequencing from GWASBadri Vardarajan
WES - Hispanics Badri Vardarajan
Hispanic GWASGiuseppe Tosto
Genetic modifiers in G206A carriers Joseph H. Lee
The role of CUGPB2 in AD using genomic and cell biology approaches Joseph H. Lee
Consortium for Alzheimer's Sequence Analysis (CASA)
WGSBadri Vardarajan/
Richard Mayeux
WES Badri Vardarajan/
Sandra Barral-Rodriguez
Replication Richard Mayeux
Miami Department of Defense (DOD) WES - Hispanics Badri Vardarajan
Epidemiology of Familial Late-Onset Alzheimer's Disease (LOAD)
Trauma and tau haplotypesBadri Vardarajan
Psychosis and AD GWAS/Linkage Sandra Barral-Rodriguez
Alzheimer's Disease Research Center at Columbia University (ADRC)
Sequencing genes in the CREB networkSandra Barral-Rodriguez
AD Genetics Core projects Richard Mayeux
Multicenter Study on Exceptional Survival in Families (LLFS)
Linkage and association and exceptional memorySandra Barral-Rodriguez
Exceptional memory and comorbidities Sandra Barral-Rodriguez
Functional GWAS of telomere in LLFS families Joseph H. Lee
The Epidemiology of Biomarkers of Risk and Progression in Late Onset Alzheimer's Disease (Biomarkers)
WHICAP various projects (Aβ, Cardiovascular, MRI, Cognitive reserve, …)Richard Mayeux
Lewy body phenotypes Giuseppe Tosto

 

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