Jahar Bhattacharya, M.D., D.Phil.

Professor of Medicine (tenured)

 

Bio

Dr. Jahar Bhattacharya, MD, DPhil, Professor of Medicine, is the Director of Lung Research at the Division of Pulmonary and Critical Care Medicine at the CUMC. He has been a researcher for over thirty years with an interest in the biology of acute lung injury. Dr. Bhattacharya graduated in medicine from the Institute of Medical Sciences (AIIMS), New Delhi, India. He was cardiology resident at the Radcliff Infirmary, Oxford, UK. Subsequently, he obtained a Ph.D. from Oxford University, and then completed his postdoctoral training at the Cardiovascular Research Institute, University of California at San Francisco. Dr. Bhattacharya's research has been supported by NIH funding and he has served on multiple NIH study sections both as permanent and ad hoc member. He serves as member of Advisory Board for the Cardiopulmonary System, Universities of Giessen, Frankfurt and Max-Planck Inst., Germany and as reviewer for multiple journals. He served on the Executive Committee of the APS Respiration Section and was Chair of the Pulmonary Circulation Assembly of the American Thoracic Society. He has given invited lectures at national and international meetings and has won awards including the Rhodes Scholarship, the American Thoracic Society's Research Recognition Award, the MERIT award of the NIH, and the Julius Comroe award of the American Physiological Society. Ongoing projects in the Bhattacharya lab continue to be focused on basic mechanisms of acute lung injury and include optical imaging studies of macrophage-epithelial interactions, mitochondrial transfer between cells, lung procoagulant mechanisms, endothelial barrier biophysics and therapeutic effectiveness of cell-penetrating peptides. Dr. Bhattacharya directs the PACC’s T32 training program.

Education and Training

Medical School:
M.B.B.S., All India Institute of Medical Sciences, New Delhi, India. 1968
Graduate:
M. Sc., Oxford University, England 1973
D. Phil., Oxford University, England 1976

Honors and Awards

  • 1970 Rhodes Scholar
  • 1973 Schorstein Lecturer, Oxford University
  • 1976 F.L. Neizer Fellow, Stanford University
  • 1985 NIH Research Career Development Award
  • 1998 NIH MERIT Award
  • 2001 American Thoracic Society (ATS) Award for Recognition of Scientific Accomplishments
  • 2007 Chair, Pulmonary Circulation Assembly, ATS
  • 2007 Member, Advisory Board, Excellence Cluster for the Cardiopulmonary System, Universities of Giessen, Frankfurt and Max-Planck Inst., Germany
  • 2008 Chair, Columbia branch of Lung Research program at University of Giessen,Germany
  • 2010 Reviewer, CSR College of Distinguished Reviewers, NHLBI
  • 2010 Member of Advisory Board, Max Planck Institute, Bad Nauheim, Germany

Research

Contact Information: 

Lung Biology Laboratory
650 West 168th Street
BB 8-812
New York, NY 10032

Lab Manager: Rashmi Patel
P: (212) 305-7310
F: (212) 305-6701
E: rnp2105@columbia.edu

Research Interests

  • Regulation of lung microvascular barrier properties in inflammation and sepsis
  • Second messenger signaling in lung endothelial cells in situ
  • Cell-cell communication in lung inflammation and sepsis
  • Regulation of alveolar surfactant secretion
  • Formation and clearance of alveolar wall liquid

Selected Funding

  • “Micropuncture Studies of Lung Water and Solute Exchange”
    Principal Investigator: Jahar Bhattacharya
    Agency: National Heart, Lung, and Blood Institute
    Type: R37 (MERIT Award) (HL36024, Years 14-23).
    Period: 06/01/98-05/31/13.
    Subject: Barrier regulation in lung microvessels.
  • “Calcium Regulation in Lung Microvascular Endothelium”
    Principal Investigator: Jahar Bhattacharya
    Agency: National Heart, Lung, and Blood Institute
    Type: RO1 (HL57556, Years 5-9). Period: 08/01/05-07/31/10.
    Subject: Ca2+ regulation in lung microvessels.
  • “Microscopic Imaging of Alveolar function”
    Principal Investigator: Jahar Bhattacharya
    Agency: National Heart, Lung, and Blood Institute
    Type: RO1 (HL64896, Years 5-8). Period: 04/01/04-03/31/12.
    Subject: Regulation of surfactant secretion in intact alveoli.
  • “Alveolo-capillary signaling in lung immunobiology”
    Principal Investigator: Jahar Bhattacharya
    Agency: National Heart, Lung, and Blood Institute
    Type: RO1 (HL69514, Years 5-9). Period: 08/01/05-07/30/10.
    Subject: Alveolar-capillary signaling.
  • “Protein therapy for acute lung injury”
    Agency: National Heart, Lung, and Blood Institute
    Type: 1RC1 (HL099389, Years 1-2). Period: 9/30/09 - 8/31/11
    Subject: Development of therapeutic agents for ALI
  • "Optical imaging of mesenchymal stem cell interations with lung microvessels"
    Principal investigator: Jahar Bhattacharya
    Agency: National Heart, Lung, and Blood Institute
    Type: RO1 (HL57556, Years 15-18). 08/01/10-07/31/14
  • "Liquid secretion in the alveolar wall"
    Principal investigator: Jahar Bhattacharya
    Agency: National Heart, Lung, and Blood Institute
    Type: RO1 (HL78645, Years 6-10). 12/01/10-11/10/14

Selected Publications

  1. Quadri, S. and J. Bhattacharya. Resealing of endothelial junctions by focal adhesion kinase. Am. J. Physiol. Lung Cell. Mol. Physiol. 2007; 292:L334-42.
  2. Lindert, J, Parthasarathi K, and Bhattacharya, J. Chloride-dependent secretion of alveolar wall liquid determined by optical-sectioning microscopy. Am. J. Resp. Cell. Mol. Biol. 2007. 36:688-96.
  3. Perlman, CE and J. Bhattacharya. Alveolar micromechanics determined by optical sectioning microscopy. J. Appl. Physiol. 2007; 103:1037-44.
  4. Bertuglia, S, Ichimura H, Fossati G, Parthasarathi K, Leoni F, Modena D, Cremonesi P, Bhattacharya J, and P. Mascagni. ITF1697, a stable Lys-Pro–containing peptide, inhibits
  5. Weibel Palade body exocytosis induced by ischemia/reperfusion and pressure elevation. Mol Med. 2007;13:615-24.
  6. Kiefmann R, Rifkind JM, Nagababu E, and J Bhattacharya. RBC induce hypoxic lung inflammation. Blood. 2008. 111:5205-14.
  7. Editorial Comment: G. Zimmerman. “Hypoxic erythrocytes spark lung leukocyte adhesion”.
  8. Azeloglu EU, J Bhattacharya and KD Costa. Atomic force microscope elastography reveals phenotypic differences in alveolar cell stiffness. J Appl Physiol. 2008;105:652-61
  9. Otsu K, S Das, SD Houser, SK Quadri, S Bhattacharya and J Bhattacharya. Concentration dependent inhibition of angiogenesis by mesenchymal stem cells. Blood. 2009; 113:4197-205.
  10. [Comment: M. Matthay. “Mesenchymally stemming angiogenesis”]
  11. Lederer DJ, S Jelic, RC Basner, A Ishizaka, and J Bhattacharya. Circulating KL-6, a biomarker of lung injury, in obstructive sleep apnea. Eur. Respir. J. 2009; 33: 793-796.
  12. Kiefmann R, MN Islam, J Lindert, K Parthasarathi, and J Bhattacharya. Paracrine purinergic signaling determines lung endothelial nitric oxide production. Am. J. Physiol. Lung Cell Mol. Physiol. 2009. 296:L901-10.
  13. Perlman, CE, J Lindert and J. Bhattacharya. The micromechanics of alveolar edema. Am. J. Resp. Cell. Mol. Biol. (In Press).

View Dr. Bhattacharya's full list of publications from PubMed

Medical Specialties

  • Pulmonary Disease Medicine