Thailand

Watch Dr. Gary Brittenham Discuss the Global Health Initiative

Gary Brittenham, Chief of the Division of Hematology has an international reputation for his work in iron metabolism and malaria. His worldwide projects are supported by the United States National Institutes of Health and involve collaborators in Bangkok, Thailand, Hong Kong, Peoples' Republic of China, and Zurich, Switzerland. Dr. Brittenham presently has four on-going projects; the first examines the effects of acute infection with Plasmodium falciparum on the absorption, pharmacokinetics and metabolism of iron from iron supplements and other iron interventions in women of childbearing age, using non-radioactive, stable isotopes of iron (54Fe, 57Fe, and 58Fe).

See The Difference We Make in Pictures

Hospital for Tropical Diseases, Mahidol University, Bangkok, Thailand

The second research project is designed to develop a multidisciplinary collaborative program focused on the neuropathological consequences of severe and cerebral malaria in Thailand, using non-invasive high-field (3.0 Tesla) magnetic resonance (MR) studies. The third initiative is attempting to identify individuals who would benefit from iron supplementation, this project will develop a portable, battery-powered instrument, similar to a digital oral thermometer in size and ease of operation, for the noninvasive measurement of erythrocyte zinc protoporphyrin under field conditions. The goal of the fourth project is to determine if iron supplements given routinely during pregnancy produce plasma non-transferrin-bound iron (NTBI: iron in the systemic circulation not bound to the iron-transport protein transferrin).

Opportunities exist for residents and fellows to participate in these projects and to work collaboratively with Dr. Brittenham who can be reached at gmb31@columbia.edu.

Global Health Projects: Gary M. Brittenham, M.D.

Project: Malaria and the safety of iron interventions: absorption and non-transferrin-bound iron
Support: National Institutes of Health, National Institute of Child Health and Human Development (NICHD) Grant Number U01 HD061233
Sites:

Bangkok, Thailand: Mahidol University, Faculty of Tropical Medicine, Bangkok Hospital for Tropical Diseases

Zürich, Switzerland: Swiss Federal Institute of Technology (ETH Zürich), Laboratory of Human Nutrition

Brief Description of Project: This research examines the effects of acute infection with Plasmodium falciparum on the absorption, pharmacokinetics and metabolism of iron from iron supplements and other iron interventions in women of childbearing age, using non-radioactive, stable isotopes of iron (54Fe, 57Fe, and 58Fe).

Project: Neuropathology of severe malaria in Thailand: MRI studies
Support: National Institutes of Health, National Institute of Neurological Disorders and Stroke (NINDS) Grant Number R21 NS055348
Sites:

Bangkok, Thailand: Mahidol University, Faculty of Tropical Medicine, Bangkok Hospital for Tropical Diseases

Bangkok, Thailand: Mahidol University, Faculty of Medicine, Ramathibodi Hospital

Brief Description of Project: Brief description of project: This research project is designed to develop a multidisciplinary collaborative program focused on the neuropathological consequences of severe and cerebral malaria in Thailand, using non-invasive high-field (3.0 Tesla) magnetic resonance (MR) studies.