Adam M. Brickman, Ph.D.
The Taub Institute for Research on Alzheimer's Disease and the Aging Brain630 West 168th St, P&S 16
Associate Professor of Neuropsychology
New York, NY 10032
The effect of age on neuromorphology and its cognitive consequences. My current research efforts focus primarily on "normal" cognitive and structural changes across the adult lifespan. Specifically, we use structural magnetic resonance imaging (MRI) to try to identify specific areas in the brain or coordinated patterns of brain tissue that are most vulnerable to the effects of age. Although age-associated decline across several neurocognitive domains has been well documented, how age-associated differences in the brain's structure impacts cognitive abilities is still poorly understood. We are addressing this issue with a focus on individual differences in cognitive aging and on potential moderators and mediators of the relationships among age, neuromorphology, and cognition. We are particularly interested in understanding how cognitive reserve and cerebrovascular risk factors interact with the aging brain and cognitive abilities. For MRI quantification, these studies use traditional manual-tracing region-of-interest (ROI) approaches, ROI templates, white matter hyperintensity quantification protocols, voxel based morphometry, and novel multivariate/covariance analytic techniques.
Other research activities. I also have interests in using structural and functional neuroimaging techniques, traditional neuropsychological approaches, and functional assessment to understand neuro/psychiatric disorders, such as schizophrenia and dementia.
Chokron, S., Brickman, A.M., Wei, T., & Buchsbaum, M.S. (2000). Hemispheric asymmetry for selective attention. Cognitive Brain Research, 9, 85-90.
Brickman, A.M., Riba, A., Bell, K., Marder, K., Albert, M., Brandt, J., & Stern, Y. (2002). Longitudinal assessment of patient dependence in Alzheimer's disease. Archives of Neurology, 59, 1304-1308.
Brickman, A.M., Buchsbaum, M.S., Shihabuddin, L., Hazlett, E.A., Borod, J.C., & Mohs, R.C. (2003). Striatal size, glucose metabolic rate, and verbal learning in normal aging. Cognitive Brain Research, 17, 106-116.
Brickman, A.M., Buchsbaum, M.S., Bloom, R., Bockhoven, Pl, Paul-Odouard, R., Haznedar, M.M., Dahlman, K.L., Hazlett, E.A., Aronowitz, J., Heath, D., & Shihabuddin, L. (in press). Neuropsychological functioning in first-break, never-medicated adolescents with psychosis. Journal of Nervous and Mental Disease, 192, 615-622
Brickman, A.M., Buchsbaum, M.S., Shihabuddin, L., Byne, W., Newmark, R.E., Brand, J., Ahmed, S., Mitelman, S.A., & Hazlett, E.A. (in press). Thalamus size and outcome in schizophrenia. Schzophrenia Research, 71, 473-484.
Brickman, A.M., Paul, R.H., Cohen, R.A., Williams, L.M., MacGregor, K.L., Jefferson, A.L., Tate, D.F., Gunstad, J., & Gordon, E. (2004). Semantic and phonemic verbal fluency across the adult lifespan: Relationship to EEG theta power. Archives of Clinical Neuropsychology, 20, 561-573.
Brickman, A.M., Buchsbaum, M.S., Ivanov, Z., Borod, J.C., Foldi, N.S., Hahn, E., Mitelman, S.A., Hazlett, E.A., Lincoln, S.J., Newmark, R.E., & Shihabuddin, L. (in press). Internal capsule size in good and poor outcome schizophrenia. Journal of Neuropsychiatry and Clinical Neurosciences.
Brickman, A.M., Cabo, R., & Manly, J.J. (in press). Ethical issues in cross cultural neuropsychology. Applied Neuropsychology.
Brickman, A.M., Habeck, C., Zarahn, E., Flynn, J., & Stern, Y. (in press). Structural MRI covariance patterns associated with normal aging and neuropsychological functioning. Neurobiology of Aging.
Brickman, A.M., Zimmerman, M.E., Paul, R.H., Grieve, S.M., Tate, D.F., Cohen, R.A., Williams, L.M., Clark, C.R., & Gordon, E. (in press). Regional white matter volume and neuropsychological functioning across the adult lifespan. Biological Psychiatry.
Stavitsky, K.*, Brickman, A.M.*, Torgan, R.L., Scarmeas, N., Tang, M.X., Albert, M., Brandt, J., Blacker, D., & Stern, Y. (in press). The progression of cognitive and functional abilities in patients with dementia with Lewy bodies and those with Alzheimer's disease. Archives of Neurology. *Both authors contributed equally to this manuscript.
Zimmerman, M.E., Brickman, A.M., Paul, R.H., Grieve, S.M., Tate, D.F., Gunstad, J., Cohen, R.A., Williams, L.M., Clark, C.R., & Gordon, E. (in press). Regional gray matter volume and neuropsychological function across the adult lifespan. American Journal of Geriatric Psychiatry.