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Sulzer lab publications
Selected references from our lab listed by area of interest.


Presynatic regulation of transmitter release (dopamine and glutamate)

Mosharov, E., and Sulzer, D. (2005).
Detailed algorithms for detection and analysis of exocytic events recorded by amperometry.
Nature Methods, 2:651-658. pdf

here is the supplementary material for that paper

Giraudo, C.G., Hu, C., You, D. Slovic, A.M., Mosharov, E., Sulzer, D., Melia, T.J., Rothman, J.E. (2005)
SNAREs can promote complete fusion and hemifusion as alternative outcomes.
Journal of Cell Biology, 2005, 170:249-260 pdf

Staal, R.G.W., Mosharov, E.V., Sulzer, D.
Dopamine neurons release transmitter via a flickering fusion pore
Nature Neuroscience 2004 7:341-346 pdf

here is a commentary on the above paper by Mark Wightman

Bamford, N.S., Zhang, H., Schmitz, Y., N.P. Wu, Cepdea, C., Levine, M.S., Schmauss, C., Zakharenko, S.S., Zablow, L., Sulzer, D.
Heterosynaptic dopamine neurotransmission selects sets of corticostriatal terminals
Neuron 2004 42, 653-663 pdf

here is a commentary on the above paper by Fu-Ming Zhou and John Dani

Zhang, H., and Sulzer, D.
Frequency-dependent modulation of dopamine release by nicotine
Nature Neuroscience, 2004 7, 581-582 pdf

here is an article on the above paper, including related studies and sociocultural analysis from Nature Medicine

Hui Zhang and David Sulzer
Glutamate spillover in the striatum depresses dopaminergic transmission by activating Group I metabotropic glutamate receptors
Journal of Neuroscience 2003 23:10585-10592 pdf

Eugene V. Mosharov, Liang-Wei Gong, Bhavanna Khanna, David Sulzer, and Manfred Lindau
Intracellular patch electrochemistry: regulation of cytosolic catecholamines in chromaffin cells
Journal of Neuroscience 2003 23:5835-5845 pdf

Yvonne Schmitz,Marianne Benoit-Marand, Francois Gonon, and David Sulzer
Presynaptic regulation of dopaminergic neurotransmission (Review)
Journal of Neurochemistry, 2003 87:273-289 pdf

Schmitz, Y., Schmauss, C., and Sulzer, D.
Altered dopamine release and uptake in mice lacking D2 receptors
Journal of Neuroscience 2002 15:8002-2009 pdf

Pothos, E., Mosharov, E., Liu, K.P., Setlik, W., Baldini, G., Gershon, M.D., Tamir, H., Sulzer, D
Stimulation-dependent regulation of secretory vesicle pH, volume, and quantal size

Journal of Physiology 2002 542:453-476 pdf

David Sulzer and Emmanuel N Pothos
Presynaptic mechanisms that regulate quantal size (Review)
Reviews in the Neurosciences 2000 11:150-212 pdf

Pothos, E., Larsen, K., Liu, Y.J. Edwards, R.H., and Sulzer, D.,
Synaptic vesicle transporter expression regulates vesicle phenotype and quantal size

Journal of Neuroscience 2000 20:7297- 7308 pdf

Abelovich, A., Schmitz, Y., Farinas, I., Choi-Lundberg, D., Ho, W.-H., Verdugo, J.M.G., Armanini, M., Ryan, A., Hynes, M., Phillips, H., Sulzer, D., Rosenthal, A.
Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system
Neuron, 2000 25:239-252 pdf

Colliver, T., Hess, E., Pothos, E.N., Sulzer, D., and Ewing, A.G.
Quantitative and statistical analysis of the shape of amperometric spikes recorded from two populations of cells
Journal of Neurochemistry, 2000 74:1086-1097 pdf

David Sulzer and Robert Edwards
Vesicles: equal in neurotransmitter concentration but not in volume
(Commentary)
Neuron, 2000 28: 5-7 pdf

Emmanuel N Pothos, Serge Przedborski, Viviana Davila, Yvonne Schmitz, and David Sulzer
D2-Like Dopamine Autoreceptor Activation Reduces Quantal Size in PC12 Cells
Journal of Neuroscience, 1998 18: 5575-5585 pdf

David Sulzer, Myra P Joyce, Ling Lin, Daron Geldwert, Suzanne N Haber, Toshiaki Hattori, and Stephen Rayport
Dopamine Neurons Make Glutamatergic Synapses In Vitro
Journal of Neuroscience, 1998 18: 4588-4602 pdf

Emmanuel N Pothos, Viviana Davila, and David Sulzer
P
resynaptic Recording of Quanta from Midbrain Dopamine Neurons and Modulation of the Quantal Size
Journal of Neuroscience, 1998 18: 4106-4118 pdf

 

Physiology of midbrain dopamine neurons

Chuhma,N., Zhang, H., Mustine, J., Sulzer, D., Hen, R., Rayport, S.G.
Dopamine neurons mediate a fast excitatory signal via glutamatergic neurotransmission.
Journal of Neuroscience, 2004 24:972-981. pdf

Viviana Davila,Zhen Yan, Liviu C. Craciun, Diomedes Logothetis, and David Sulzer
D3 Dopamine Autoreceptors Do Not Activate G-Protein-Gated Inwardly Rectifying Potassium Channel Currents in Substantia Nigra Dopamine Neurons
Journal of Neuroscience, 2003, 23:5693-5697 pdf

David Sulzer and Aurelio Galli
Transporter currents are promoted from curiosity to physiology (Review)
Trends in Neuroscience, 2003 26: 173-6 pdf

David Sulzer and Stephen Rayport
Dale's principle and glutamate corelease from ventral dopamine neurons (REVIEW)
Amino Acids 2000, 19:45-52 pdf

David Sulzer, Myra P Joyce, Ling Lin, Daron Geldwert, Suzanne N Haber, Toshiaki Hattori, and Stephen Rayport
Dopamine Neurons Make Glutamatergic Synapses In Vitro
Journal of Neuroscience, 1998 18: 4588-4602 pdf

Stephen Rayport, David Sulzer, Wei-Xi Shi, Saswana Sawasdikosol, Jacqueline Monaco, Diedre Batson, and Geetha Rajendran
Identified postnatal mesolimbic dopamine neurons in culture: morphology and electrophysiology
Journal of Neuroscience, 1992 12: 4264-4280 pdf

 

Psychostimulant drug mechanisms of action

David Sulzer, Mark Sonders, Nathan W. Poulsen, and Aurelio Galli
Mechanisms of neurotransmitter release by amphetamines: a review
Progress in Neurobiology, 2005 75:406-433. pdf

Eugene V. Mosharov, Liang-Wei Gong, Bhavanna Khanna, David Sulzer, and Manfred Lindau
Intracellular patch electrochemistry: regulation of cytosolic catecholamines in chromaffin cells
Journal of Neuroscience, 2003 23:5835-5845 pdf

Kristin Larsen, Edward Fon, Terry G. Hastings, Robert H. Edward, R.H., and David Sulzer
Methamphetamine -induced degeneration of dopaminergic neurons involves autophagy and upregulation of dopamine synthesis
Journal of Neuroscience, 2002 22:8951-8960 pdf

Yvonne Schmitz,Y., C. Justin Lee, Claudia Schmauss, Francois Gonon, and David Sulzer
Amphetamine distorts synaptic dopamine overflow: effects on vesicular stores, D2 autoreceptors, and uptake
Journal of Neuroscience, 2001 21: 5916-5924 pdf

Edward Fon, Emmanuel N Pothos, Bao-Cun Sun, Nigel Killeen, David Sulzer and Robert H Edwards
Vesicular transport regulates monoamine storage and release but Is not essential for amphetamine action
Neuron 19: 1271-1283. pdf

David Sulzer, Ta-Kung Chen, Yau-Yi Lau, Helle Kristensen, Stephen Rayport, and Andrew Ewing
Amphetamine redistributes dopamine from synaptic vesicles to the cytosol and promotes reverse transport
Journal of Neuroscience, 1995 15: 4102-4108 pdf

Joseph F Cubells, Stephen Rayport, Geetha Rajendran, and David Sulzer
Methamphetamine neurotoxicity involves vacuolation of endocytic organelles and dopamine-dependent intracellular oxidative stress
Journal of Neuroscience, 1994 14: 2260-2271 pdf

David Sulzer and Stephen Rayport
Amphetamine and other psychostimulants reduce pH gradients in midbrain dopaminergic neurons and chromaffin granules: a mechanism of action
Neuron, 1990 5: 797-808 [Abstract only]

 

Parkinson's Disease and neurodegeneration

Ana Maria Cuervo, Leo Stefanis, Ross Fredenburg, Peter Lansbury, David Sulzer
Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy
Science 2004 305:1292-5 pdf

Stan Fahn and David Sulzer
Neurodegeneration and neuroprotection in Parkinson's Disease
NeuroRx 2004 1:139-154 pdf

Luigi Zecca, Fabio Zucca, Henrik Wilms and David Sulzer
Neuromelanin of the substantia nigra: a neuronal black hole with protective and toxic characteristics
TRENDS in Neurosciences, 2003, 26:216-220 pdf

Larsen, K., and Sulzer, D.
Autophagy in neurons: a review
Histology & Histopathology, 2002, 17:897-908
pdf

Luigi Zecca, Ruggero Fariello, Peter Riederer, David Sulzer, Alberto Gatti, Davide Tampellini
The absolute concentration of nigral neuromelanin, assayed by a new sensitive method, increases throughout the life and is dramatically decreased in Parkinson's disease
FEBS Letters, 2002, 510: 216-220 pdf

David Sulzer
Alpha-synuclein and cytosolic dopamine; stabilizing a bad situation (Commentary)
Nature Medicine, 2001, 12: 1280-1282 pdf

Stefanis, L., Larsen, K.E., Rideout, H.J., Sulzer, D., and Greene, L.A.
Expression of A53T mutant, but not wild type, alpha-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death
Journal of Neuroscience, 2001 21, 9549-9560
pdf

Petersen, A., Behr, G.G., Larsen, K., Romero, N., Przedborski, S., Brundin, P., Sulzer, D.
An expanded CAG repeat in exon 1 of the Huntington's Disease gene promotes dopamine-mediated autophagy and death in striatal neurons
Hum. Mol. Genet., 2001 10:1243-54 pdf

Zecca, L., Tampellini, D., Gerlach, M., Riederer, P., Fariello, R.G., and Sulzer, D. (2001)
Substantia nigra neuromelanin: structure, synthesis and molecular behaviour
(Review)
J. Clinical Pathol. 2001 54:414-418 pdf

Sulzer, D., Bogulavsky, J., Larsen, K.E., Karatekin, E., Kleinman, M., Turro, N., Kranz, D., Edwards, R., Greene, L.A., Zecca, L.
Neuromelanin synthesis sequesters cytosolic catecholamines not accumulated by synaptic vesicles
Proc Natl Acad Sci USA, 2000 97:11869-11874. pdf

Abelovich, A., Schmitz, Y., Farinas, I., Choi-Lundberg, D., Ho, W.-H., Verdugo, J.M.G., Armanini, M., Ryan, A., Hynes, M., Phillips, H., Sulzer, D., Rosenthal, A.
Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system
Neuron, 2000 25:239-252. pdf

David Sulzer and Luigi Zecca
Intraneuronal dopamine-quinone biosynthesis: a review
Neurotoxicity Research, 2000 1:181-195 pdf

Kholidov, N.G., Neystat, M., Oo, T.F., Larsen, K.E., Sulzer, D., and Burke, R.E.
Increased expression of rat synuclein 1 in the substantia nigra compacta identified by mRNA differential display in a model of developmental target injury
Journal of Neurochemistry, 1999: 73:2586-2599. pdf

Mena, M.A., Davila, V., Bogaluvsky, J., and Sulzer, D.
L-DOPA potentiates NGF-induced outgrowth and quantal dopamine release in PC12 neurites.
Molecular Pharmacol., 1998 54:678-686. pdf

Robert E Burke, Megan Antonelli, and David Sulzer
Glial Cell Line-Derived Neurotrophic Growth Factor Inhibits Apoptotic Death of Postnatal Substantia Nigra Dopamine Neurons in Primary Culture
Journal of Neurochemistry, 1998 71, 517-525. pdf

Maria Angeles Mena, Viviana Davila, and David Sulzer
Neurotrophic Effects of L-DOPA in Postnatal Midbrain Dopamine Neuron/Cortical Astrocyte Cocultures
Journal of Neurochemistry, 1997 69, 1398-1408. pdf

Serge Przedborski, Uzma Khan, Vladimir Kostic, Elaine Carlson, Charles J Epstein, and David Sulzer
Increased Superoxide Dismutase Activity Improves Survival of Cultured Postnatal Midbrain Neurons
Journal of Neurochemistry, 1996, 67, 1383-1392 pdf


| Research directions | Contact lab members | Home |Downloads, Tutorials, etc.