COMPREHENSIVE EPILEPSY CENTER
» Comprehensive Epilepsy Center
Clinical Epilepsy Research
Carl W. Bazil
» Columbia University Sleep Disorders Center
Investigational drug trials in epilepsy; relationships between sleep, sleep disorders, and epilepsy; influences of sleep on memory and learning.
Decision analysis. Patient preference assessment. Development of patient decision aid. Outcomes in intractable epilepsy.
Catherine Schevon, Ronald Emerson
Electrophysiology of epileptic brain, signal processing of EEG recordings, and application to seizure localization and prediction; physiological basis of electroencephalography (EEG); electrophysiology-based techniques for functional mapping in children and adults.
Marla J. Hamberger
Pre and postoperative language and memory in epilepsy; new approaches to assess word finding; cortical stimulation language mapping, naming studies using fMRI; language and memory during intracarotid amobarbital testing.
Studies of the effects of epilepsy and antiepileptic drugs on bone metabolism.
Neuroendocrine and reproductive aspects of epilepsy; human sexuality; women's issues related to epilepsy.
Pregnancy and epilepsy; juvenile myoclonic epilepsy; non-surgical treatment of epilepsy.
W. Allen Hauser
Neuroepidemiology of seizures and epilepsy with specific interests in identifying and quantitating risk factors for seizure occurrence, the prognosis of seizures and epilepsy, and the consequences of head trauma.
Family and genetic studies of epilepsy. Identification of genes that influence risk for seizures and epilepsy.
Neuroepidemiology of seizure disorders and consequences of severe head injury. Association between MRI-detected brain abnormalities and development among children with febrile seizures, prognosis for status epilepticus, and risk factors for newly diagnosed epilepsy. Impact of the acute management of severe brain injury on outcome (in collaboration with the Brain Trauma Foundation).
Guy M. McKhann, II
Role of astrocytes in epilepsy; glia-neuron interactions.
Translational neuroscience is the main interest of the laboratory. Current projects include examining the role of Brain derived neurotrophic factor (BDNF) in seizures and epilepsy using animal models of the disease; abnormal neurogenesis in neurological disorders; looking at the effects of the hormones estrogen and testosterone on excitability of brain regions; and looking at the way water balance, controlled by water channels (aquaporins) in glia (support cells in the brain), regulate the response to traumatic brain injury and seizures.
Family and genetic studies of epilepsy; problems in phenotype definition; linkage analysis and delineation of human epilepsy susceptibility genes.