CUMC Irving Institute/Clinical Trials Office Pilot Award

Anette Wu, MD, PhD

Induction of Liver Allograft Tolerance through Bone Marrow Transplantation: Translational Preclinical Pilot Study in Monkeys
Background: Despite improvements in short-term results following solid organ allotransplantation, long-term results have not been significantly altered over the past decade. Vasculopathy, infections, and malignancies that develop in chronically suppressed recipients of otherwise successful allografts and emphasize the limitations of current immunosuppressive approaches. Therefore, induction of specific transplantation tolerance remains a major goal of clinical organ transplantation. The long-term goal of our studies is to develop reliable clinical regimens that can induce allograft tolerance in various organ transplants without the need for immunosuppression.